Glycoprotein is the proteins with oligosaccharide moieties which emerge after glycosylation during post-translational or co-translational modification of proteins.
Glycoprotein plays a crucial role in cellular metabolism and functions including cell signalling, cellular adhesion, immune system, pathogenicity, genesis and progression of metabolic disease and biomarker of diseases such as cancer.
There Glycosylations are of two types, O-glycosylation on Serine (Ser) or Threonine (Thr) residues and N-glycosylation on Aspargine (Asn) residue with the consensus sequence of Asn-X-Ser, where X is any amino acid except proline (Pro).
Glycoprotein analysis can be instrumental for understanding its structure and function and its role in the underlined diseases prognosis and their therapy. The global glycoprotein analysis market is anticipated to grow with the advancing research of glycoprotein into chronic diseases.
Coronavirus has leveraged the global glycoprotein analysis market growth. Coronavirus glycoprotein coat is actively dwelled to decode the pathogenicity and develop vaccine or therapies for the novel-virus.
Immunoblotting analysis, epitope mapping, chromatography, spectrometry and many others are actively implemented for research and glycoprotein analysis
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Glycoprotein Analysis Market: Drivers and Restraints
The global glycoprotein analysis market driver includes the massive research and technology for glycoprotein analysis to unravel their structure and function. Glycoprotein analysis has a huge market base in food consumption bacterial and yeast protein production and healthcare.
Also the advancing R&D technology and investments into glycoprotein analysis for drugs therapies vaccines disease progression understanding the biology of glycoprotein and product launches.
Glycoprotein analysis is has massive rseaech involvement into cancer of breast prostate and ovary malfunctioning glycoprotein associated enzyme and metabolism aberrations resulting in glycoprotein storage diseases including Alpha-Mannosidosis Aspartylglucosaminuria and Beta-Mannosidosis.
Glycoprotein analysis has attracted huge R&D investments subsidization and reimbursements for glycoprotein associated antibodies mutations and associated pathway targeting which altogether propels the glycoprotein analysis market growth.
However the smooth growth of glycoprotein analysis market is halted due to low abundance of native target glycoproteins purification enrichment and fractionation issues simultaneous glycoprotein sequencing glycan moieties and glycosylation sites analysis.
Glycoprotein analysis gets complex due to the increasing heterogeneity of glycan structures. Glycoprotein analysis requires further sensitive and quantitative methods for the urgent detection of specific glycoform and its role in disease progression.
Glycoprotein analysis techniques such as spectroscopy and chemical reagents are expensive labour-intensive and the dearth of research and medical professionals decelerates the growth of glycoprotein analysis market.
Despite these constraints global glycoprotein analysis market is poised to grow lucratively due to the progressing R&D and healthcare and investments driven by the vast application of glycoprotein in healthcare and food.
The novel analysis methods with improved accuracy sensitivity and efficacy and cost-effectiveness which will propel the global glycoprotein analysis market furthermore.
Glycoprotein Analysis Market: Overview
The global glycoprotein analysis market is growing lucratively with the technological advancements of glycoprotein analysis for research healthcare and food. By glycosylation the global glycoprotein analysis glycosylation is divided into N-linkage and O-linkage which have a crucial role in the progression and therapy of several diseases.
N-glycosylation plays crucial role in arthritis cancer diabetes Crohn’s diseases and several nervous system diseases. N-linked glycoprotein is found in therapeutic antibodies including Rituximab Etanercept and Infliximab. O-glycosylation is involved in antibody structure analysis and development targeting of Alzheimer diseases and cancers by O-glycan structure and terminal Lewis epitopes.
By end-users the global glycoprotein analysis techniques have major contributions from hospital and research institutes and their collision for glycoprotein associates diseases diagnosis and analysis. The glycoprotein analysis data from research institutes are crucial for the diagnosis.
By techniques mass spectrometry dominates the glycoprotein analysis technique due to their sensitivity specificity speed and stoichiometry for the glycoprotein identification glycosylation site and glycan structures.
Major spectrometry techniques for glycoprotein analysis include mass spectrometry (MS) Electrospray ionization mass spectrometry (ESI-MS) matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and hydrophilic interaction chromatography-mass spectrometry (HILIC-MS).
Glycoprotein Analysis Market: Key Players
The key players of the global glycoprotein analysis market include
- Sigma-Aldrich. BD
- Enzo Life Sciences
- Creative Diagnostics
- Thermo Fisher Scientific
- Epitope Diagnostics Inc.
- R&D Systems
- QED Bioscience Inc
- ACROBiosystems.
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