The global Hutchinson Gilford Progeria Syndrome Therapeutics Market Size is predicted to generate a market value of US$ 103.07 billion in 2023 and a market value of US$ 233.05 billion by 2033, with a CAGR of 8.5% from 2023 to 2033. The expansion of the Hutchinson-Gilford progeria syndrome market can be ascribed to the world’s growing population, which is contributing to an increase in cases of the illness. From 2017 to 2022, the market for Hutchinson Gilford Progeria Syndrome grew at a CAGR of 5.5%.
Hutchinson-Gilford Progeria Syndrome (HGPS), also known as Progeria, is an extremely rare genetic disorder characterized by rapid aging in children. It is caused by a mutation in the LMNA gene, which leads to the production of an abnormal form of the protein lamin A. This protein plays a crucial role in maintaining the structure of the nucleus in cells. As a result of the mutation, affected children experience a range of symptoms including growth failure, hair loss, wrinkled skin, joint stiffness, cardiovascular problems, and a higher susceptibility to fractures. The average life expectancy for individuals with Progeria is around 14 years, although some may live into their early 20s with proper medical care.
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Although there is currently no cure for Progeria, research efforts have focused on developing treatments to manage its symptoms and improve the quality of life for affected individuals. A drug called lonafarnib has shown promise in clinical trials, helping to improve weight gain, cardiovascular function, and overall survival. Additionally, ongoing research continues to shed light on the underlying mechanisms of the disease, providing valuable insights into the aging process in general. Progeria serves as a unique model for studying age-related diseases and may contribute to advancements in understanding the biology of aging and potential treatments for age-related conditions.
Market Drivers
Scientists from the Agency for Science, Technology, and Research (A*STAR) recently constructed a model of Hutchinson-Gilford progeria syndrome. This organization’s research offered a model that suggests progerin is linked to telomeres. Progerin reduces heterochromatin, a tightly packed form of DNA, making telomeres more brittle and vulnerable to damage in the cell. Telomere damage results in premature cellular ageing. This model differs significantly from the previous one in that the gene progerin caused the nucleus to be distorted, reducing cells’ ability to divide and proliferate. The altered progerin protein renders the nuclear membrane fragile and gradually destroys the nucleus, increasing the likelihood of early cell death.
Market Restraints
The main factor impeding market expansion is the lack of correct medicine and treatment for Hutchinson-Gilford progeria syndrome. Despite spending money on research and development, no positive outcomes have been obtained. As a result, discovering the right treatment for Hutchinson-Gilford’s progeria syndrome has been delayed and prolonged.
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Furthermore, Hutchinson-Gilford progeria syndrome begins to manifest after two years. This has resulted in people delaying their treatment intake. Furthermore, a lack of understanding among healthcare professionals and the general public is impeding the expansion of the Hutchinson-Gilford progeria syndrome market.
Regional Insights
North America is predicted to dominate the Progeria treatment market in terms of market share and revenue during the forecast period. This is due to increased healthcare infrastructure and the region’s strong presence of important businesses.
For example, the Progeria Research Foundation in the United States is the only organisation in the world committed to finding therapies and a cure for children with Progeria. They created the ‘Find the Children’ project to look for undiagnosed children with Progeria so that they, too, can receive the necessary specialised care. As a result, North America is estimated to hold 45% of the Hutchinson-Gilford progeria syndrome market in 2023.
During the projected period, increased healthcare spending by a substantial segment of the population in emerging nations such as India and China is expected to fuel the region’s progeria market. As a result, Asia Pacific is estimated to account for 40% of the Hutchinson-Gilford progeria syndrome market in 2023.
Competitive Landscape
Key players in the Hutchinson-Gilford progeria syndrome market Eiger BioPharmaceuticals, Teva Pharmaceutical, Inc., Amgen, Sanofi, Novartis AG, Schering-Plough, PRG Science & Technology Co., Ltd, Micro Interventional Devices Inc, Boston Scientific Corporation, CryoLife Inc.
- Micro Interventional Devices Inc, a key player in the Hutchinson Gilford Progeria Syndrome market is focusing on investing in research and development for innovating medications for treating Hutchinson-Gilford progeria syndrome.
- Boston Scientific Corporation, another key player in the Hutchinson Gilford Progeria Syndrome market has undertaken extensive research to innovate medication and treatment to increase the life cycle of patients suffering from Hutchinson Gilford Progeria Syndrome.
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