The global Alpha-1 Antitrypsin Deficiency (AATD) treatments market is expected to increase at a compound annual growth rate of 12.8% to reach US$ 10 billion by 2033 from its estimated US$ 3 billion market value in 2023. One of the primary drivers of market expansion is the rising incidence of respiratory conditions. Furthermore, the market is expanding due to the increasing usage of augmentation therapy.
By separating the protein from the blood plasma of healthy donors, augmentation therapy aims to raise the concentration of AAT in the respiratory tracts of patients. This therapy slows the progression of the emphysema, minimizes the frequency of exacerbations, and expedites recovery. These elements support its growing acceptance among patients and medical professionals.
Investments in research and development (R&D) are also anticipated to have a significant effect on the industry. By utilizing their existing strengths and broadening them through strategic alliances, R&D, and potential licensing, merger, and acquisition operations, many companies are striving to build a portfolio that has the potential to change the direction of company.
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Key Takeaways from the Market Study
- The global alpha-1 antitrypsin insufficiency market is expected to develop at a 12.8% CAGR by 2033, according to FMI.
- The global market for Alpha-1 Antitrypsin Deficiency is anticipated to be over US$ 3 billion.
- The global market for Alpha-1 Antitrypsin Deficiency is expected to be around US$ 10 billion.
- According to Future Market Insights, Asia Pacific will grow at a CAGR of 12% between 2023 and 2033.
- North America is expected to grow at a 12.7% CAGR between 2023 and 2033.
- Europe is expected to grow at a 12.3% CAGR between 2023 and 2033.
“Within North America, the United States has dominated the market. The rising number of government funding, developments in gene therapy research and development, and the rising penetration of target illnesses are the primary drivers driving the Alpha-1 Antitrypsin Deficiency market expansion,” says an analyst at FMI
Market Competition
To address the present patient pool’s requests and counter the therapeutic market’s unmet needs, drug developers are increasingly moving their focus to alpha-1 antitrypsin deficiency (AATD).
Many novel medicines are being developed by several businesses, including ARO-AAT (Arrowhead Pharmaceutical), Alvelestat (Mereo Biopharma), and Inhaled AAT (Kamada).
ARO-AAT (Arrowhead Pharmaceutical) is a second-generation subcutaneously given drug that lowers hepatic synthesis of the mutant AAT protein by knocking down the alpha-1 antitrypsin (AAT) gene transcript. The business is now undertaking Phase II clinical studies to assess the drug’s safety, tolerability, and pharmacodynamic impact in AATD patients.
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Key players in the Alpha-1 Antitrypsin Deficiency (A1ATD) market are:
- Pfizer
- Baxter
- AstraZeneca
- Grifols
- Teva Pharmaceutical Industries
- BoehringerIngelheim
- Kamada Ltd
- GlaxoSmithKline
- CSL Behring
- LFB Biomedicaments
Recent Developments:
Kamada Ltd., a vertically integrated global biopharmaceutical company focused on specialty plasma-derived therapeutics, announced in October 2022 that it had been awarded a three-year extension of an existing tender from the Canadian Blood Services (CBS) for the supply of four IgG products, CYTOGAM®, HEPAGAM®, VARIZIG®, and WINRHO® SDF, for a total estimated value of US$ 22 million. This award ensures that such products will continue to be sold in Canada. In November 2021, Kamada purchased four commercial pharmaceuticals that have been licensed by Health Canada and the United States Food and Drug Administration (FDA).
Key Segments Profiled in the Alpha-1 Antitrypsin Deficiency Market Industry Survey
By Product Type:
- Augmentation Therapy
- Bronchodilators
- Corticosteroids
- Oxygen Therapy
By Application:
- Hospitals
- Specialty Clinics
- Pharmacies
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