The cholesterol active pharmaceutical ingredient (API) market is on a trajectory of steady growth, with an expected valuation of USD 280.6 million in 2023. According to recent forecasts, the market is projected to grow at a compound annual growth rate (CAGR) of 4.7% during the period from 2023 to 2033, reaching an estimated USD 445.3 million by 2033.
Cholesterol APIs, primarily sourced from animal-derived sources, accounted for approximately 52.38% of the market share in 2022. This dominance is expected to continue, driven by their widespread use in pharmaceutical formulations targeting cardiovascular health and other medical applications.
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The anticipated surge in the worldwide market for medications that lower cholesterol serves as a reminder of the growing importance and awareness of cholesterol control in the medical community. Cardiovascular diseases continue to be one of the leading causes of death worldwide, which is driving rising demand for cholesterol-lowering medications. This presents a compelling opportunity for research and development funding from pharmaceutical industry participants, encouraging innovation and accessibility in the production of cholesterol APIs.
Growth in Cholesterol-Lowering Drugs is Driven by Innovation:
Significant progress has been made in the development of medications that decrease cholesterol in recent years. Regulatory bodies have authorized novel medication classes, including selective cholesterol absorption inhibitors, bile acid sequestrants, and PCSK9 inhibitors. Clinical trials using these medications have shown encouraging results in reducing LDL (bad) cholesterol levels. The need for the APIs that enable these drugs is fueled by this innovation in pharmaceuticals.
Government Programs Encourage Control of Cholesterol:
The increasing prevalence of CVDs is being actively addressed by governments and healthcare institutions around the world. Programs for screening for cholesterol, public awareness campaigns, and attempts to increase accessibility for cholesterol-lowering drugs are among the initiatives. The demand for cholesterol APIs has surged as a direct result of these initiatives.
Competitive Landscape:
There are many different firms in the highly fragmented worldwide cholesterol API market. In order to address the increasing demand from consumers and broaden their clientele, these businesses are employing several tactics such mergers and acquisitions, joint ventures, cooperative efforts, and the introduction of new products.
The following are a few recent changes in the worldwide cholesterol API market:
Sanofi Consumer Healthcare Korea and AB-BIOTICS collaborated in June 2023 to launch probiotics in South Korea that have benefits beyond enhancing intestinal health. Assisting people in controlling their cholesterol levels is its main goal. The Ministry of Food and Drug Safety has approved it as the first probiotic product. The South Korean market is renowned for being more open to using probiotics for a range of medical applications.
ProBiotix Health introduced a dual-action cholesterol pill in May 2023. This novel tablet lowers the absorption of dietary cholesterol while simultaneously assisting the liver in removing cholesterol from the bloodstream.
- In May 2022, Sun Pharma revealed that its fully-owned subsidiary is going to soon introduce a new oral medication called Bempedoic Acid in India. This drug is specifically designed to lower low-density lipoprotein (LDL) cholesterol levels. The subsidiary plans to market the drug in India using the brand name Brillo.
- The US Food and Drug Administration approved Regeneron Pharmaceuticals, Inc.’s Evkeeza in February 2021 to be used in conjunction with other treatments aimed at lowering low-density lipoprotein cholesterol (LDL-C) levels. Notably, Evkeeza is the first FDA-approved medication that binds to and inhibits the function of angiopoietin-like 3 (ANGPTL3), an essential protein involved in the metabolism of lipids.
- The signing of an R&D collaboration agreement to strengthen their position in the field of lipid nanoparticles (LNP) formulations was announced by CordenPharma and Wacker in December 2021.
- Centrient Pharmaceuticals, a top supplier of sustainable antibiotics and next-generation statins, began producing its innovative statins manufacturing facility in June 2021. To help satisfy the increasing demand for Rosuvastatin and Atorvastatin APIs, the business plans to quadruple its statin production capacity.
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Key Market Players
- Merck KGaA
- Cayman Chemical Company (Matreya)
- CordenPharma
- Croda International Plc (Avanti)
- NOF (Nippon Oil & Fats) Corporation
- Nippon Fine Chemical Co. Ltd.
- Akums Drugs & Pharmaceuticals Ltd
- Tokyo Chemical Industry Co., Ltd.
- Evonik Industries AG
- Dishman Group
- Hänseler AG
- Caesar & Loretz GmbH
- Fisher Scientific Co, LLC (Thermo Fisher)
Cholesterol API Market Outlook by Category:
By Source:
- Animal Derived
- Plant Derived
- Synthetic
By Manufacturing Process:
- GMP
- Non – GMP
By End User:
- RNA Vaccines
- Monoclonal Antibodies
- Others
By Region:
- North America
- Latin America
- Europe
- South Asia
- East Asia
- Oceania
- The Middle East and Africa (MEA)
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